Diagnostic accuracy testing

diagnostic accuracy studyA newer procedure, laboratory test, investigation or chemical method is frequently tested on a group of study subjects in presence of a gold standard. In this backdrop, researcher is keen to know the diagnostic accuracy of newer procedure, laboratory test or investigative method in comparison to existing test or gold standard.

Diagnostic accuracy analysis involves computation of various operating characteristics like sensitivity, specificity, positive & negative predictive values, likelihood ratios for positive and negative tests. Area under curve (AUC) is also estimated for discriminatory ability of newer test or method using receiver operating characteristic curve (ROC) analysis.